現在地

HO KIONG(ホー キョン; Ho, Kiong)

所属
医学医療系
職名
准教授
URL
eメール
 
研究分野
機能生物化学
寄生虫学(含衛生動物学)
分子生物学
研究キーワード
RNA Processing, RNA ligation, Trypanosoma
研究課題
Mechanism of mRNA recapping pathway in trypanosome2016-04 -- 2020-03HO KIONG日本学術振興会/科研費/基盤研究(B)14320000
Structural, Functional and Genetic Analysis of Archaea RNA Ligase2011-04 -- 2016-03Kiong Hoアメリカ国立科学財団/Div Of Molecular and Cellular Bioscience76500000
Mechanism of mRNA cap formation in Trypanosoma brucei2006-07 -- 2011-06HO KIONGアメリカ心臓協会/Scientist Development Grant26000000
Mechanism of Archaeal RNA ligase2007-07 -- 2008-09HO KIONGUniversity at Buffalo/UB2020 Interdisciplinary Research Development Fund4000000
職歴
2003-01 -- 2010-10ニューヨーク州立大学、バッファロー校 Department of Biological Sciences 助教授
2000-01 -- 2003-10スローンケタリンがん研究所 Program in Molecular Biology 主任研究員
1997-04 -- 1999-12スローンケタリンがん研究所(米国) Program in Molecular Biology Post-doctoral Fellow
学歴
1986-09 -- 1990-01米国ラトガース大学 ニュージャージー州立大学 生命理工学部 B.A. 生物化学卒業
1990-09 -- 1997-03米国コーネル大学医科学大学院 分子生物 Ph.D. 分子生物卒業
所属学協会
-- (現在)RNA Society (International)
論文
  • A Yeast-like mRNA Capping Apparatus in Plasmodium falciparum
    Ho CK; Shuman S
    Proc. Natl. Acad. Sci. USA/98(6)/pp.3050-3055, 2001-03
  • A Yeast-Based Genetic System for Functional Analysis of Viral mRNA Capping Enzymes
    Ho CK; Martins A; Shuman S
    JOURNAL OF VIROLOGY/74(12)/pp.5486-5494, 2000-06
  • RNA Triphosphatase Component of the mRNA Capping Apparatus of Paramecium bursaria Chlorella Virus
    Ho CK; Gong C; Shuman S
    JOURNAL OF VIROLOGY/75/pp.1744-1750, 2001-02
  • Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis
    Gu H; Yoshionari S; Ghosh R; Ignatochkina AV; Gollnick PD...
    Nucleic acids research/44(5)/pp.2337-2347, 2016-03
  • Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase
    Paul Smith; Ho Kiong; Yuko Takagi; Hakim Djaballah; Stewa...
    mBIO/7(1)/p.10.1128/mBio.00058-16 , 2016-02
  • The messenger RNA decapping and recapping pathway in Trypanosoma
    Ignatochkina AV; Takagi Y; Liu Y; Negate K; Ho Kiong
    Proceedings of the National Academy of Sciences USA/112(22)/pp.6967-6972, 2015-06
  • Teaching science and learning English: an introduction to the Molecular Biology Course in Vietnam
    Ho Kiong
    The Journal of Medical English Education/14(3)/pp.93-98, 2015-10
  • Archaea RNA Ligase is a Homodimeric Protein that Catalyzes Intramolecular Ligation of Single-Stranded RNA and DNA.
    Torchea C Takagi Y and Ho CK.
    Nucleic Acid Research/36/p.6218-6227, 2008-01
  • Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events.
    Dong H; Ray D; Ren S; Zhang B; Puig-Basagoiti F; Takagi Y...
    J. Virol./81/p.4412-4421, 2007-01
  • Trypanosoma brucei Encodes a Bifunctional Capping Enzyme Essential for Cap 4 Formation on the Spliced Leader RNA.
    Takagi Y Sindkar S Ekonomidis D Hall MP and Ho CK.
    J. Biol. Chem/282/p.15995-16005, 2007-01
  • Functional Characterization of a 48-kDa Trypanosoma brucei Cap 2 RNA Methyltransferase.
    Hall MP and Ho CK.
    Nucleic Acid Research/34/p.5594 - 5602, 2006-01
  • Characterization of a Trypanosoma brucei mRNA Cap (Guanine N-7) Methyltransferase.
    Hall MP and Ho CK.
    RNA/12/p.488 -497, 2006-01
  • Identification of the MicroRNAs of the Herpesvirus Family.
    Pfeffer S Sewer A Lagos-Quintana M Sheridan R Sander C Gr...
    Nature Method/2/p.269-276, 2005-01
  • Structure and Mechanism of RNA Ligase.
    Ho CK Wang LK Lima CD and Shuman S.
    Structure/12/p.327-339, 2004-01
  • Characterization of Bacteriophage KVP40 and T4 RNA Ligase 2.
    Yin S Ho CK Miller ES and Shuman S.
    Virology/319/p.141-151, 2004-01
  • Portability and Fidelity of RNA Repair Systems.
    Schwer B; Sawaya R; Ho CK; Shuman S.; +HO KIONG
    Proc. Natl. Acad. Sci. USA/101/p.2788-2793, 2004-01
  • Mutation Analysis of Bacteriophage T4 RNA Ligase 1: Differential Functional Group are Required for the Nucleotidyl Transfer and Phosphodiester Bond Formation Steps of the Ligation Reaction.
    Wang LK Ho CK Pei Y and Shuman S.
    J. Biol. Chem./278/p.17601-17608, 2003-01
  • RNA Substrate Specificity and Structure-Guided Mutational Analysis of T4 RNA Ligase 2.
    Nandakumar J Ho CK Lima CD and Shuman S.
    J. Biol. Chem./279/p.31337-31347, 2003-01
  • Bacteriophage T4 RNA Ligase 2 (gp 24.1) Exemplifies a Family of RNA Ligases Found in All Phylogenic Domains.
    Ho CK and Shuman S.
    Proc. Natl. Acad. Sci. USA/99/p.12709-12714, 2002-01
  • Tat Stimulates Cotranscriptional Capping of HIV-1 mRNA.
    Chiu YL; Ho CK; Saha N; Schwer B; Shuman S; and Rana TM.;...
    Molecular Cell/10/p.585-597, 2002-01
  • Importance of Homodimerization for the in vivo Function of Yeast RNA Triphosphatase.
    Lehman K Ho CK and Shuman S.
    J. Biol. Chem./276/p.14996-15002, 2001-01
  • Structure and Mechanism of the RNA Triphosphatase Component of Mammalian mRNA Capping Enzyme.
    Changela A; Ho CK; Martins A; Shuman S; and Mondragon A.;...
    EMBO J./20/p.2575-2586, 2001-01
  • The Length, Primary Structure and Phosphorylation State of the RNA Polymerase II CTD Dictate Interactions with the mRNA Capping Enzymes.
    Pei Y; Hausmann S; Ho CK; Schwer B; and Shuman S.; +HO KIONG
    J. Biol. Chem./276/p.28075-28082, 2001-01
  • Trypanosoma brucei RNA Triphosphatase: Anti-Protozoal Drug Target and Guide to Eukaryotic Phylogeny.
    Ho CK; Shuman S.; HO KIONG
    J. Biol. Chem./276/p.46182-46186, 2001-01
  • An Essential Function of Saccharomyces cerevicieae RNA Triphosphatase Cet1 is to Stabilize RNA Guanylyltransferase Ceg1 Against Thermal Inactivation.
    Hausmann S Ho CK Schwer B and Shuman S.
    J. Biol. Chem./276/p.36116-36124, 2001-01
著書
会議発表等
  • Inhibitor Screening Against Trypanosoma cruzi RNA Triphosphatase
    Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Tani Osamu; Saka...
    Kinetoplastid Molecular Cell Biology 2017/2017-04-22--2017-04-26
  • Archaea RNA Ligase is Required for Circularizing Small Non-Coding RNA.
    Ho Kiong; Liu Yancheng; Takagi Yuko; Hirata Akira; Hori H...
    第19回日本RNA学会/2017-07-19--2017-07-21
  • Trypanaosome mRNA recapping activity is modulated by hypermethylation derived from cap 4 structure
    Ho Kiong; Ignatochkina Anna V.; Iguchi Jesavel; Kore Anil...
    第19回日本RNA学会/2017-07-19--2017-07-21
担当授業科目
2017-10 -- 2018-02国際実践医科学研究特論I筑波大学
2017-04 -- 2017-08国際実践医科学研究特論I筑波大学
2017-10 -- 2018-02国際実践医科学研究特論III筑波大学
2017-04 -- 2017-08国際実践医科学研究特論III筑波大学
2017-04 -- 2017-08Advanced Exercise on Public Health筑波大学
2017-10 -- 2018-02Advanced Exercise on Public Health筑波大学
2017-10 -- 2018-02国際実践医科学研究特論II筑波大学
2017-04 -- 2017-08国際実践医科学研究特論II筑波大学
2017-10 -- 2018-02インターンシップII筑波大学
2017-04 -- 2017-08インターンシップII筑波大学
授業以外の教育活動
2016-01 -- 2016-01Advanced Biotechnology and MedicineHCMC University of Science Vietnam
2015-01 -- 2015-01Advanced Biotechnology and MedicineHCMC University of Science Vietnam
2014-01 -- 2014-01Advanced Molecular BiologyHCMC University of Science Vietnam
2014-03 -- 2014-03Molecular Biology Course in VietnamUniversity of Tsukuba & Institute of Tropical Biology
2015-01 -- 2015-01Molecular Biology Course in VietnamUniversity of Tsukuba & Institute of Tropical Biology
2016-01 -- 2016-01Molecular Biology Course in VietnamUniversity of Tsukuba & Institute of Tropical Biology
2016-07 -- 2016-08Summer Research Program in Tsukuba 2016筑波大学
2015-07 -- 2015-08Summer Research Program in Tsukuba 2015筑波大学
2014-07 -- 2014-08Summer Research Program in Tsukuba 2014筑波大学
2013-07 -- 2013-08Summer Research Program in Tsukuba 2013筑波大学

(最終更新日: 2017-08-09)