Ho Kiong

Affiliation
Institute of Medicine
Official title
Associate Professor
URL
Email
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Research fields
Parasitology (including sanitary zoology)
Functional biochemistry
Molecular biology
Research keywords
Parasitology, RNA Processing, RNA ligation, Trypanosoma
Research projects
Structure and biological targets of Trypanosome mRNA recapping enzyme2021 -- 2023HO KIONGJapan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)4,290,000Yen
Mechanism of mRNA recapping pathway in trypanosome2016-04 -- 2020-03HO KIONG日本学術振興会/科研費/Scientific Research Basic B14,320,000Yen
Structural, Functional and Genetic Analysis of Archaea RNA Ligase2011-04 -- 2016-03Kiong HoNational Science Foundation/Div Of Molecular and Cellular Bioscience76,500,000Yen
Mechanism of mRNA cap formation in Trypanosoma brucei2006-07 -- 2011-06HO KIONGAmerican Heart Association/Scientist Development Grant26,000,000Yen
Mechanism of Archaeal RNA ligase2007-07 -- 2008-09HO KIONGUniversity at Buffalo/UB2020 Interdisciplinary Research Development Fund4,000,000Yen
Career history
2003-01 -- 2010-10State University of New York at BuffaloDepartment of Biological SciencesAssistant Professor
2000-01 -- 2003-10Sloan Kettering Instite for Cancer ResearchProgram in Molecular BiologySenior Research Scientist
1997-04 -- 1999-12Sloan Kettering Institute for Cancer ResearchProgram in Molecular BiologyPost-doctoral Fellow
Academic background
1986-09 -- 1990-01Rutgers University, The State University of New Jersey College of Arts and Sciences Biochemistry
1990-09 -- 1997-03Cornell University, Weill Graduate School of Medical Sciences Molecular Biology Molecular Biology
Degree
1997-02Ph.D. Molecular BiologyCornell University, Weill Graduate School of Medical Sciences
1990-1Bachelor of Arts, BiochemistryRutgers College, State University of New Jersey, USA
Academic societies
2020-01 -- 2020-12American Society for Biochemistry and Molecular Biology
1997-01 -- 2020-12ASM (American Society of Microbiology)
2017-04 -- (current)THE JAPANESE SOCIETY OF PARASITOLOGY
2007-01 -- 2020-03RNA Society (International)
2017-04 -- (current)THE RNA SOCIETY OF JAPAN
Articles
  • Factors Affecting Undergraduate Medical Science Students’ Motivation to Study during the COVID-19 Pandemic
    Mayers Thomas David; Mathis Bryan J.; Ho C. Kiong; Morika...
    Education Sciences/12(9), 2022-09
    Tsukuba Repository
  • Editorial: mRNA Translational Control as a Mechanism of Post-transcriptional Gene Regulation
    Kiss L. Daniel; Vasudevan Deepika; Ho Kiong; Caliskan Neva
    FRONTIERS IN MOLECULAR BIOSCIENCES/9, 2022-06
  • Genetic and functional analyses of archaeal ATP-dependent RNA ligase in C/D box sRNA circularization and ribosomal RNA processing
    Liu Yancheng; Takagi Yuko; Sugijanto Milyadi; Nguyen Kie...
    FRONTIERS IN MOLECULAR BIOSCIENCES/9, 2022-03
    PubMed
  • The impact of the COVID-19 pandemic on medical science students’ motivation to study: Preliminary findings
    Mayers Thomas David; Mathis Bryan J; Ho Kiong; Morikawa ...
    Journal of Medical English Education./20(3)/pp.52-55, 2021-10
  • An essential surface motif (WAQKW) of yeast RNA triphosphatase mediates formation of the mRNA capping enzyme complex with RNA guanylyltransferase
    Ho Kiong; Lehman Kevin; Shuman Stewart
    Nucleic Acids Research/27(24)/pp.4671-4678, 1999-01
    PubMed
  • Advanced Topics in Biotechnology and Medicine: An intensive literature-based course to encourage critical thinking in science and build academic English skills
    Ho C. Kiong; Mayers Thomas David; Morikawa Kazuya; Watana...
    Journal of Medical English Education/20(3)/pp.39-46, 2021-10
  • Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
    Mayers Thomas; Morikawa Kazuya; Fukuda Aya; Watanabe Yuk...
    J Med Eng Educ/19(1)/pp.40-44, 2020-02
  • Crystal structures of the RNA triphosphatase from Trypanosoma cruzi provide insights into how it recognizes the 5' end of the RNA substrate
    Takagi Yuko; Kuwabara Naoyuki; Dang Truong Tat; Furukawa ...
    Journal of Biological Chemistry/295(27)/pp.9076-9086, 2020-05
    PubMed Tsukuba Repository
  • Mutational Analyses of Yeast RNA Triphosphatases Highlight a Common Mechanism of Metal-dependent NTP Hydrolysis and a Means of Targeting Enzymes to Pre-mRNAs in Vivo by Fusion to the Guanylyltransferase Component of the Capping Apparatus
    Pei Yi; Ho Kiong; Schwer Beate; Shuman Stewart
    Journal of Biological Chemistry/274(41)/pp.28865-28874, 1999-10
  • An international exchange program for undergraduate medical science students.
    Mayers Thomas; Morikawa Kazuya; Ho Kiong; Ohneda Osamu
    J Med Eng Educ/17(1)/pp.7-13, 2018-04
  • Cleavage of 3'-terminal adenosine by archaeal ATP-dependent RNA ligase
    Yoshinari Shigeo; Liu Yancheng; Gollnick Paul; Ho C Kiong
    Scientific reports/7(1), 2017-09
    PubMed Tsukuba Repository
  • Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis
    Gu H; Yoshionari S; Ghosh R; Ignatochkina AV; Gollnick PD; Mur...
    Nucleic acids research/44(5)/pp.2337-2347, 2016-03
    PubMed Tsukuba Repository
  • Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase
    Paul Smith; Ho Kiong; Yuko Takagi; Hakim Djaballah; Stewart S...
    mBIO/7(1)/p.10.1128/mBio.00058-16, 2016-02
    PubMed Tsukuba Repository
  • Teaching science and learning English: an introduction to the Molecular Biology Course in Vietnam
    Ho Kiong
    The Journal of Medical English Education/14(3)/pp.93-98, 2015-10
  • The messenger RNA decapping and recapping pathway in Trypanosoma
    Ignatochkina AV; Takagi Y; Liu Y; Negate K; Ho Kiong
    Proceedings of the National Academy of Sciences USA/112(22)/pp.6967-6972, 2015-06
    PubMed
  • Archaea RNA Ligase is a Homodimeric Protein that Catalyzes Intramolecular Ligation of Single-Stranded RNA and DNA.
    Torchea C Takagi Y and Ho CK.
    Nucleic Acid Research/36/p.6218-6227, 2008-01
  • Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events.
    Dong H; Ray D; Ren S; Zhang B; Puig-Basagoiti F; Takagi ...
    J. Virol./81/p.4412-4421, 2007-01
  • Trypanosoma brucei Encodes a Bifunctional Capping Enzyme Essential for Cap 4 Formation on the Spliced Leader RNA.
    Takagi Y Sindkar S Ekonomidis D Hall MP and Ho CK.
    J. Biol. Chem/282/p.15995-16005, 2007-01
  • Characterization of a Trypanosoma brucei mRNA Cap (Guanine N-7) Methyltransferase.
    Hall MP and Ho CK.
    RNA/12/p.488 -497, 2006-01
  • Functional Characterization of a 48-kDa Trypanosoma brucei Cap 2 RNA Methyltransferase.
    Hall MP and Ho CK.
    Nucleic Acid Research/34/p.5594 - 5602, 2006-01
  • Identification of the MicroRNAs of the Herpesvirus Family.
    Pfeffer S Sewer A Lagos-Quintana M Sheridan R Sander...
    Nature Method/2/p.269-276, 2005-01
  • Structure and Mechanism of RNA Ligase.
    Ho CK Wang LK Lima CD and Shuman S.
    Structure/12/p.327-339, 2004-01
  • Portability and Fidelity of RNA Repair Systems.
    Schwer B; Sawaya R; Ho CK; Shuman S.; +HO KIONG
    Proc. Natl. Acad. Sci. USA/101/p.2788-2793, 2004-01
  • Characterization of Bacteriophage KVP40 and T4 RNA Ligase 2.
    Yin S Ho CK Miller ES and Shuman S.
    Virology/319/p.141-151, 2004-01
  • RNA Substrate Specificity and Structure-Guided Mutational Analysis of T4 RNA Ligase 2.
    Nandakumar J Ho CK Lima CD and Shuman S.
    J. Biol. Chem./279/p.31337-31347, 2003-01
  • more...
Books
Conference, etc.
  • University of Tsukuba Joint Symposium in Biomedical Science
    Ho Kiong
    The 3rd University of Science – University of Tsukuba Joint Symposium in Biomedical Science/2023-02-18--2023-02-18
  • The Identification and Characterization of RNA Recapping Targets in Trypanosomes
    Ho Kiong
    The 3rd University of Science – University of Tsukuba Joint Symposium in Biomedical Science/2023-02-18--2023-02-18
  • Unique Cap-dependent RNA Methyltransferase activity in Trypanosoma brucei
    Ho Kiong
    The 23rd Annual Meeting of the RNA Society/2022-07-20--2022-07-22
  • Circularization of C/D Box sRNA by Archaeal ATP-Dependent RNA Ligase.
    Ho Kiong
    23rd Annual RNA Meeting Japan/2022-07-20--2022-07-22
  • Modification Beyond the Hypermethylated Cap 4 Structure in Trypanosoma Spliced Leader RNA
    Ho Kiong
    92nd Annual Meeting of the Japanese Society for Parasitology./2023-03-30--2023-03-31
  • Medical science summer research program in the University of Tsukuba in the era of COVID-19
    Mayers Thomas David; Ho C. Kiong
    The 55th Annual Meeting of the Japan Society for Medical Education/2023-07-28--2023-07-29
  • The impact of the COVID-19 pandemic on medical science students’ motivation to study
    Mayers Thomas David; Mathis Bryan James; Ho C. Kiong; Mor...
    24th JASMEE Academic Meeting/2021-07-17--2021-07-18
  • Purification of a Putative Cap-dependent RNA Methyltransferase in Trypanosoma brucei
    Ho Kiong; Anna Ignatochkina
    3rd - Tsukuba Purification Forum/2021-02-19--2021-02-19
  • Regulation of Protozoa Gene Expression by mRNA Recapping Pathway
    Ho Kiong
    The 2nd Joint Young Researcher Meeting in Biomedical Sciences/2020-01-10--2020-01-11
  • Crystal structure of Trypanosoma RNA triphosphatase illuminates the mechanism of triphosphate and nucleic acid recognition.
    Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Truong Dang; Fur...
    The 42nd Annual Meeting of the Molecular Biology Society of Japan/2019-12-03--2019-12-06
  • Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
    Mayers Thomas David; Ho Kiong; Fukuda Aya; Watanabe Yuki...
    The 22nd JASMEE Academic Meeting/2019-08-03--2019-08-04
  • Involving high school students in medical science exchange programs: Experiences from the University of Tsukuba
    Mayers Thomas David; Ho Kiong; Fukuda Aya; Watanabe Yuki...
    The 22nd JASMEE Academic Meeting/2019-08-03--2019-08-04
  • Targeting of mRNA Cap Formation for Treatment of Parasitic Infections
    Ho Kiong
    The Joint Symposium in Infectious Diseases/2019-02-22--2019-02-22
  • Structural and Functional Analysis of protozoan mRNA capping enzyme
    HO KIONG
    20th RNA Meeting in Japan/2018-07-09--2018-07-12
  • The messenger RNA recapping pathway in Trypanosome
    Ho Kiong
    88th Japan Parasitology Meeting/2019-03-14--2019-03-16
  • Structural and Functional Analysis of Trypanosoma RNA Triphosphatase
    HO KIONG
    第88回日本寄生虫学会大会/2019-03-14--2019-03-16
  • RNA methylation at the 5’-end of the mRNA stimulates Trypanosoma mRNA recapping activities
    Ho Kiong
    Cold Spring Harbor Meeting, Translational Control Meeting/2018-09-04--2018-09-08
  • Structure and mechanism of archaeal ATP-dependent RNA ligase
    Ho Kiong; Yoshinari Shigeo; Murakami Katsuhiko S.
    Cutting Edge Developments in RNA Biology for the Control of Gene Expression/2017-11-13--2017-11-17
  • Messenger RNA recapping enzyme is regulated by hypermethylation at the 5’-end of the RNA
    Ho Kiong; Ignatochkina Anna V.; Iguchi Jesavel; Kore Ani...
    Cutting Edge Developments in RNA Biology for the Control of Gene Expression/2017-11-13--2017-11-17
  • Molecular Mechanism of mRNA Recapping in Trypanosome
    HO KIONG
    2017年度生命科学系学会合同年次大会/2017-12-06--2017-12-09
  • Identification and characterization of a novel 5'-monophosphate RNA kinase in Trypanosoma brucei
    Ho Kiong
    21th Annual RNA Society Meeting/2016-06-28--2016-07-02
  • Recapping the Message: The mRNA Decapping and Recapping Pathway in Trypanosomes
    Ho Kiong
    21th Annual RNA Society International Meeting/2016-06-28--2016-07-02
  • Inhibitor Screening Against Trypanosoma cruzi RNA Triphosphatase
    Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Tani Osamu; Saka...
    Kinetoplastid Molecular Cell Biology 2017/2017-04-22--2017-04-26
  • Archaea RNA Ligase is Required for Circularizing Small Non-Coding RNA.
    Ho Kiong; Liu Yancheng; Takagi Yuko; Hirata Akira; Hori ...
    RNA Meeting 2017 in Toyama/2017-07-19--2017-07-21
  • Trypanaosome mRNA recapping activity is modulated by hypermethylation derived from cap 4 structure
    Ho Kiong; Ignatochkina Anna V.; Iguchi Jesavel; Kore Ani...
    RNA Meeting 2017 in Toyama/2017-07-19--2017-07-21
Teaching
2023-10 -- 2024-02Medical Science Seminar in Infectious DiseaseUniversity of Tsukuba.
2023-10 -- 2024-02Seminars on Global Issues B-IUniversity of Tsukuba.
2024-01 -- 2024-02Practical English For Lab TechniquesUniversity of Tsukuba.
2023-10 -- 2024-02Basic Experiments in Human BiologyUniversity of Tsukuba.
2023-04 -- 2023-08Special Practice in Human Biology IIIUniversity of Tsukuba.
2023-10 -- 2024-02Special Practice in Human Biology IIIUniversity of Tsukuba.
2023-10 -- 2024-02International Medical Sciences Exchange Program IIIUniversity of Tsukuba.
2023-04 -- 2023-08International Medical Sciences Exchange Program IIIUniversity of Tsukuba.
2023-10 -- 2024-02International Medical Sciences Exchange Program IIUniversity of Tsukuba.
2023-04 -- 2023-08International Medical Sciences Exchange Program IIUniversity of Tsukuba.
more...
Other educational activities
2022-02 -- 2022-02Infection Biology Workshop
2022-10 -- 2022-10Summer Research Program Plus 2022フロンティア医科学
2022-07 -- 2022-07Summer Research Program Online 2022
2023-02 -- 2023-02Undergraduate Medical Science Course in Tsukuba
2022-02 -- 2022-02Medical Science Course in Tsukuba OnlineUniveristy of Tsukuba, Undergraduate Medical Science
2021-09 -- 2021-09Summer Research Program 2021 Online
2020-10 -- 2021-01BIOINFORMATICS IN GENOMICS: Data analysis in high-throughput sequencingMasafumi Muratani, Kiong Ho
2020-12 -- 2021-02Academic Communications. Presenting, Writing, DiscussngThomas Mayers, Kiong Ho
2020-01 -- 2020-01Transcriptosome Analysis, Experimental Course in Biotechnology and MedicineUniversity of Indonesia Medical Campus
2020-01 -- 2020-01Transcriptosome Analysis, Experimental Course in Biotechnology and MedicineUniversity of Medicine and Pharmacy, Vietnam
more...
Talks
  • Purification of a Putative Cap-dependent RNA Methyltransferase in Trypanosoma brucei
    Ho Kiong; Anna Ignatochkina
    3rd Tsukuba Purification Forum/2021-02-19--2021-02-19
  • Structure and Mechanism of RNA Repair Enzymes
    Ho Kiong
    生命と機能とかたち/2018-03-07--2018-03-07
University Management
2018-04 -- (current)全学 学群教育課程委員会委員
2020-04 -- (current)全学 国際交流支援室企画・審査委員会委員
2020-04 -- (current)全学 海外生教育プログラム等検討委員会委員
2018-04 -- (current)全学 国際戦略委員会委員
2021-04 -- (current)医学医療系　国際連携委員会委員長
2021-04 -- (current)医学医療系　企画委員会委員
2019-04 -- (current)ヒューマンバイオロジープログラム 学位審査委員会委員長
2014-04 -- (current)HBP Publicity CommitteeMember
2013-04 -- (current)HBP International AffairsMember
2020-04 -- (current)医学学位プログラム 国際推進委員会委員
more...
Other activities
2021-04 -- (current)Frontiers in Molecular Bioscience - Associate Editor

(Last updated: 2023-12-06)