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Ho Kiong

Affiliation
Faculty of Medicine
Official title
Associate Professor
URL
Email
 
Research fields
Functional biochemistry
Parasitology (including sanitary zoology)
Molecular biology
Research keywords
RNA Processing, RNA ligation, Trypanosoma
Research projects
Mechanism of mRNA recapping pathway in trypanosome2016-04 -- 2020-03HO KIONG日本学術振興会/科研費/Scientific Research Basic B14320000
Structural, Functional and Genetic Analysis of Archaea RNA Ligase2011-04 -- 2016-03Kiong HoNational Science Foundation/Div Of Molecular and Cellular Bioscience76500000
Mechanism of mRNA cap formation in Trypanosoma brucei2006-07 -- 2011-06HO KIONGAmerican Heart Association/Scientist Development Grant26000000
Mechanism of Archaeal RNA ligase2007-07 -- 2008-09HO KIONGUniversity at Buffalo/UB2020 Interdisciplinary Research Development Fund4000000
Career history
2003-01 -- 2010-10State University of New York at Buffalo Department of Biological Sciences Assistant Professor
2000-01 -- 2003-10Sloan Kettering Instite for Cancer Research Program in Molecular Biology Senior Research Scientist
1997-04 -- 1999-12Sloan Kettering Institute for Cancer Research Program in Molecular Biology Post-doctoral Fellow
Academic background
1986-09 -- 1990-01Rutgers University, The State University of New Jersey College of Arts and Sciences B.A. BiochemistryGraduated
1990-09 -- 1997-03Cornell University, Weill Graduate School of Medical Sciences Ph.D. Molecular Biology Molecular BiologyGraduated
Academic societies
-- (current)RNA Society (International)
Articles
  • A Yeast-like mRNA Capping Apparatus in Plasmodium falciparum
    Ho CK; Shuman S
    Proc. Natl. Acad. Sci. USA/98(6)/pp.3050-3055, 2001-03
  • A Yeast-Based Genetic System for Functional Analysis of Viral mRNA Capping Enzymes
    Ho CK; Martins A; Shuman S
    JOURNAL OF VIROLOGY/74(12)/pp.5486-5494, 2000-06
  • RNA Triphosphatase Component of the mRNA Capping Apparatus of Paramecium bursaria Chlorella Virus
    Ho CK; Gong C; Shuman S
    JOURNAL OF VIROLOGY/75/pp.1744-1750, 2001-02
  • Structural and mutational analysis of archaeal ATP-dependent RNA ligase identifies amino acids required for RNA binding and catalysis
    Gu H; Yoshionari S; Ghosh R; Ignatochkina AV; Gollnick PD...
    Nucleic acids research/44(5)/pp.2337-2347, 2016-03
  • Nanomolar Inhibitors of Trypanosoma brucei RNA Triphosphatase
    Paul Smith; Ho Kiong; Yuko Takagi; Hakim Djaballah; Stewa...
    mBIO/7(1)/p.10.1128/mBio.00058-16 , 2016-02
  • The messenger RNA decapping and recapping pathway in Trypanosoma
    Ignatochkina AV; Takagi Y; Liu Y; Negate K; Ho Kiong
    Proceedings of the National Academy of Sciences USA/112(22)/pp.6967-6972, 2015-06
  • Teaching science and learning English: an introduction to the Molecular Biology Course in Vietnam
    Ho Kiong
    The Journal of Medical English Education/14(3)/pp.93-98, 2015-10
  • Archaea RNA Ligase is a Homodimeric Protein that Catalyzes Intramolecular Ligation of Single-Stranded RNA and DNA.
    Torchea C Takagi Y and Ho CK.
    Nucleic Acid Research/36/p.6218-6227, 2008-01
  • Distinct RNA Elements Confer Specificity to Flavivirus RNA Cap Methylation Events.
    Dong H; Ray D; Ren S; Zhang B; Puig-Basagoiti F; Takagi Y...
    J. Virol./81/p.4412-4421, 2007-01
  • Trypanosoma brucei Encodes a Bifunctional Capping Enzyme Essential for Cap 4 Formation on the Spliced Leader RNA.
    Takagi Y Sindkar S Ekonomidis D Hall MP and Ho CK.
    J. Biol. Chem/282/p.15995-16005, 2007-01
  • Functional Characterization of a 48-kDa Trypanosoma brucei Cap 2 RNA Methyltransferase.
    Hall MP and Ho CK.
    Nucleic Acid Research/34/p.5594 - 5602, 2006-01
  • Characterization of a Trypanosoma brucei mRNA Cap (Guanine N-7) Methyltransferase.
    Hall MP and Ho CK.
    RNA/12/p.488 -497, 2006-01
  • Identification of the MicroRNAs of the Herpesvirus Family.
    Pfeffer S Sewer A Lagos-Quintana M Sheridan R Sander C Gr...
    Nature Method/2/p.269-276, 2005-01
  • Structure and Mechanism of RNA Ligase.
    Ho CK Wang LK Lima CD and Shuman S.
    Structure/12/p.327-339, 2004-01
  • Characterization of Bacteriophage KVP40 and T4 RNA Ligase 2.
    Yin S Ho CK Miller ES and Shuman S.
    Virology/319/p.141-151, 2004-01
  • Portability and Fidelity of RNA Repair Systems.
    Schwer B; Sawaya R; Ho CK; Shuman S.; +HO KIONG
    Proc. Natl. Acad. Sci. USA/101/p.2788-2793, 2004-01
  • Mutation Analysis of Bacteriophage T4 RNA Ligase 1: Differential Functional Group are Required for the Nucleotidyl Transfer and Phosphodiester Bond Formation Steps of the Ligation Reaction.
    Wang LK Ho CK Pei Y and Shuman S.
    J. Biol. Chem./278/p.17601-17608, 2003-01
  • RNA Substrate Specificity and Structure-Guided Mutational Analysis of T4 RNA Ligase 2.
    Nandakumar J Ho CK Lima CD and Shuman S.
    J. Biol. Chem./279/p.31337-31347, 2003-01
  • Bacteriophage T4 RNA Ligase 2 (gp 24.1) Exemplifies a Family of RNA Ligases Found in All Phylogenic Domains.
    Ho CK and Shuman S.
    Proc. Natl. Acad. Sci. USA/99/p.12709-12714, 2002-01
  • Tat Stimulates Cotranscriptional Capping of HIV-1 mRNA.
    Chiu YL; Ho CK; Saha N; Schwer B; Shuman S; and Rana TM.;...
    Molecular Cell/10/p.585-597, 2002-01
  • Importance of Homodimerization for the in vivo Function of Yeast RNA Triphosphatase.
    Lehman K Ho CK and Shuman S.
    J. Biol. Chem./276/p.14996-15002, 2001-01
  • Structure and Mechanism of the RNA Triphosphatase Component of Mammalian mRNA Capping Enzyme.
    Changela A; Ho CK; Martins A; Shuman S; and Mondragon A.;...
    EMBO J./20/p.2575-2586, 2001-01
  • The Length, Primary Structure and Phosphorylation State of the RNA Polymerase II CTD Dictate Interactions with the mRNA Capping Enzymes.
    Pei Y; Hausmann S; Ho CK; Schwer B; and Shuman S.; +HO KIONG
    J. Biol. Chem./276/p.28075-28082, 2001-01
  • Trypanosoma brucei RNA Triphosphatase: Anti-Protozoal Drug Target and Guide to Eukaryotic Phylogeny.
    Ho CK; Shuman S.; HO KIONG
    J. Biol. Chem./276/p.46182-46186, 2001-01
  • An Essential Function of Saccharomyces cerevicieae RNA Triphosphatase Cet1 is to Stabilize RNA Guanylyltransferase Ceg1 Against Thermal Inactivation.
    Hausmann S Ho CK Schwer B and Shuman S.
    J. Biol. Chem./276/p.36116-36124, 2001-01
Books
Conference, etc.
  • Identification and characterization of a novel 5'-monophosphate RNA kinase in Trypanosoma brucei
    Ho Kiong
    21th Annual RNA Society Meeting/2016-06-28--2016-07-02
  • Recapping the Message: The mRNA Decapping and Recapping Pathway in Trypanosomes
    Ho Kiong
    21th Annual RNA Society International Meeting/2016-06-28--2016-07-02
  • Inhibitor Screening Against Trypanosoma cruzi RNA Triphosphatase
    Ho Kiong; Takagi Yuko; Kuwabara Naoyuki; Tani Osamu; Saka...
    Kinetoplastid Molecular Cell Biology 2017/2017-04-22--2017-04-26
  • Archaea RNA Ligase is Required for Circularizing Small Non-Coding RNA.
    Ho Kiong; Liu Yancheng; Takagi Yuko; Hirata Akira; Hori H...
    RNA Meeting 2017 in Toyama/2017-07-19--2017-07-21
  • Trypanaosome mRNA recapping activity is modulated by hypermethylation derived from cap 4 structure
    Ho Kiong; Ignatochkina Anna V.; Iguchi Jesavel; Kore Anil...
    RNA Meeting 2017 in Toyama/2017-07-19--2017-07-21
Teaching
2017-10 -- 2018-02International Medical Sciences Exchange Program IUniversity of Tsukuba.
2017-04 -- 2017-08International Medical Sciences Exchange Program IUniversity of Tsukuba.
2017-10 -- 2018-02International Medical Sciences Exchange Program IIIUniversity of Tsukuba.
2017-04 -- 2017-08International Medical Sciences Exchange Program IIIUniversity of Tsukuba.
2017-04 -- 2017-08Advanced Exercise on Public HealthUniversity of Tsukuba.
2017-10 -- 2018-02Advanced Exercise on Public HealthUniversity of Tsukuba.
2017-10 -- 2018-02International Medical Sciences Exchange Program IIUniversity of Tsukuba.
2017-04 -- 2017-08International Medical Sciences Exchange Program IIUniversity of Tsukuba.
2017-10 -- 2018-02Internship IIUniversity of Tsukuba.
2017-04 -- 2017-08Internship IIUniversity of Tsukuba.
Other educational activities
2016-01 -- 2016-01Advanced Biotechnology and MedicineHCMC University of Science Vietnam
2015-01 -- 2015-01Advanced Biotechnology and MedicineHCMC University of Science Vietnam
2014-01 -- 2014-01Advanced Molecular BiologyHCMC University of Science Vietnam
2014-03 -- 2014-03Molecular Biology Course in VietnamUniversity of Tsukuba & Institute of Tropical Biology
2015-01 -- 2015-01Molecular Biology Course in VietnamUniversity of Tsukuba & Institute of Tropical Biology
2016-01 -- 2016-01Molecular Biology Course in VietnamUniversity of Tsukuba & Institute of Tropical Biology
2016-07 -- 2016-08Summer Research Program in Tsukuba 2016筑波大学
2015-07 -- 2015-08Summer Research Program in Tsukuba 2015筑波大学
2014-07 -- 2014-08Summer Research Program in Tsukuba 2014筑波大学
2013-07 -- 2013-08Summer Research Program in Tsukuba 2013筑波大学

(Last updated: 2017-08-17)