Nishikii Hidekazu

Affiliation

Institute of Medicine

Official title

Associate Professor

Research projects

ヒト造血幹細胞の不均一性の解明と機能制御	2022 -- 2024	錦井 秀和	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,160,000Yen
造血器腫瘍における造血ニッチ細胞の遺伝子・機能異常解析	2018 -- 2020	錦井 秀和	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,550,000Yen
同種骨髄移植後の新規免疫モニタリングシステムと免疫寛容メカニズムの解明	2015 -- 2017	錦井　秀和	Japan Society for the Promotion of Science/Grant-in-Aid for Scientific Research(C)	4,810,000Yen
巨核球・血小板分化における転写因子ＨＥＳ１が担う制御機構の解明	2012 -- 2013		Japan Society of for the Promotion of Science/若手研究(B)	2,080,000Yen
巨核球分化におけるＮｏｔｃｈシグナルが担う造血制御機構	2010 -- 2011		Japan Society of for the Promotion of Science/若手研究(B)	4,030,000Yen

Degree

2008-03	博士(医学)	University of Tokyo

Articles

• Activated mesenchymal stem/stromal cells promote myeloid cell differentiation via CCL2/CCR2 signaling
  Yamazaki Satoshi; Mabuchi Yo; Kimura Takaharu; Suto E...
  Stem cell reports/19(3)/pp.414-425, 2024-02-29
  
  PubMed
• Impact of CD34 positive cell dose in donor graft on the outcomes after haploidentical peripheral blood stem cell transplantation with post-transplant cyclophosphamide - A retrospective single-center study with a Japanese cohort
  Maruyama Yumiko; Nishikii Hidekazu; Kurita Naoki; Sakamot...
  Blood cells, molecules & diseases/105, 2023-12-30
  
  PubMed
• Purging myeloma cell contaminants and simultaneous expansion of peripheral blood-mobilized stem cells
  Ishitsuka Kantaro; Nishikii Hidekazu; Kimura Takaharu; ...
  Experimental hematology/131, 2023-12-25
  
  PubMed
• Risk factors for CAR-T cell manufacturing failure among DLBCL patients: A nationwide survey in Japan
  Jo Tomoyasu; Yoshihara Satoshi; Okuyama Yoshiki; Fujii...
  British journal of haematology/202(2)/pp.256-266, 2023-04-25
  
  PubMed
• 同種造血幹細胞移植により長期寛解を得たCLEC16A::IL2融合遺伝子を有するT細胞前リンパ球性白血病
  百瀬 春佳; 栗田 尚樹; 錦井 秀和; 遊佐 希; 横山 和明; 清水 英吾; 井元 清哉; 南木 融; 丸山 ...
  臨床血液/65(1)/pp.35-40, 2024-01
  
  PubMed
• Safety of romiplostim administered immediately after cord-blood transplantation: a phase 1 trial
  Kurita Naoki; Nishikii Hidekazu; Maruyama Yumiko; Suehara...
  ANNALS OF HEMATOLOGY/102(10)/pp.2895-2902, 2023-08-17
  
  PubMed
• Repeated immunosuppressive rabbit antithymocyte globulin therapy for adult patients with relapsed or refractory aplastic anemia
  Sakamoto Tatsuhiro; Obara Naoshi; Maruyama Yumiko; Kato ...
  EUROPEAN JOURNAL OF HAEMATOLOGY/111(5)/pp.768-776, 2023-08-07
  
  PubMed
• Tumor Necrosis Factor from Leukemic Microenvironment Provides Non-Leukemic Hematopoietic Stem Cells with Megakaryocyte Lineage Bias
  Nishikii Hidekazu; Saito Mizuki; Kimura Takaharu; Kiyo...
  BLOOD/140(1)/pp.5774-5775, 2022-11
• Efficacy and Safety of Emicizumab Prophylaxis in Patients with Acquired Hemophilia a Who Were Deemed Ineligible for Immunosuppressive Therapy: Additional Data from the Ageha Study
  Nishikii Hidekazu; Suzuki Nobuaki; Kobayashi Ryota; Mi...
  BLOOD/140(1)/pp.2724-2725, 2022-11
• Elongation of Long-Chain Fatty Acids Is Crucial for Hematopoietic Stem Cell Engraftment and Leukemia Propagation
  Kato Takayasu; Kiyoki Yusuke; Kito Sakura; Matsuzaka ...
  BLOOD/140(1), 2022-11
• Safety proof of romiplostim immediately after cord-blood transplantation: Results of a phase 1 trial
  Kurita N.; Maruyama Y.; Suehara Y.; Hattori K.; Kato ...
  BONE MARROW TRANSPLANTATION/57(SUPPL 1:1)/pp.346-346, 2022-11
• A Single-Cell Atlas of Nonhematopoietic Cells in Human Lymph Node and Lymphoma Reveals Landscape of Stromal Remodeling
  Abe Yoshiaki; Sakata-Yanagimoto Mamiko; Fujisawa Manabu; ...
  BLOOD/138(1), 2021-11
• [Acute myeloid leukemia harboring NUP98::DDX10]
  Kurita Naoki; Kato Takayasu; Nanmoku Toru; Maruyama Yumi...
  [Rinsho ketsueki] The Japanese journal of clinical hematology/63(10)/pp.1397-1401, 2022-10
  
  PubMed
• The fatty acid elongase Elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation
  Kiyoki Yusuke; Kato Takayasu; Kito Sakura; Matsuzaka ...
  LEUKEMIA/37(4)/pp.910-913, 2023-03-08
  
  PubMed
• Chemically defined cytokine-free expansion of human haematopoietic stem cells
  Sakurai Masatoshi; Ishitsuka Kantaro; Ito Ryoji; Wilki...
  NATURE/615(7950)/pp.127-133, 2023-02
  
  PubMed
• Novel translocation of POGZ/STK11 in de novo mast cell leukemia with KIT D816H mutation
  Ishitsuka Kantaro; Yoshizawa Yuki; Nishikii Hidekazu; Kus...
  LEUKEMIA & LYMPHOMA/63(14)/pp.3475-3479, 2022-09
  
  PubMed
• [Lymphoplasmacytic lymphoma accompanied by severe myelofibrosis]　
  Takarada Ayako; Momose Haruka; Kurita Naoki; Matsuoka Ry...
  [Rinsho ketsueki] The Japanese journal of clinical hematology/64(1)/pp.54-59, 2023-01
  
  PubMed
• [Hematopoietic recovery by ASXL1-mutated clones after immune suppressive therapy in a patient with severe aplastic anemia]
  Shimizu Yumoe; Nishikii Hidekazu; Iitsuka Tadashi; Matsuo...
  [Rinsho ketsueki] The Japanese journal of clinical hematology/64(1)/pp.49-53, 2023-01
  
  PubMed
• Waldenström macroglobulinemia complicated by peripheral neuropathy due to neural infiltration
  Norioka Natsuki; Kurita Naoki; Kamura Yuya; Sakamoto Tat...
  [Rinsho ketsueki] The Japanese journal of clinical hematology/64(1)/pp.18-22, 2023-01
  
  PubMed
• Hemolysis induced by SARS-CoV-2 mRNA vaccination in patients with paroxysmal nocturnal hemoglobinuria
  Kamura Yuya; Sakamoto Tatsuhiro; Yokoyama Yasuhisa; Nishi...
  INTERNATIONAL JOURNAL OF HEMATOLOGY/116(1:SI)/pp.55-59, 2022-06
• Triple-negative Thrombocythemia and Subsequent Acute Lymphoblastic Leukemia with Additional Somatic Mutations
  Tsuboi Yuri; Sakamoto Tatsuhiro; Makishima Kenichi; Su...
  Internal medicine (Tokyo, Japan)/62(10)/pp.1527-1530, 2022-09-13
  
  PubMed
• Administration of brentuximab vedotin to a Hodgkin lymphoma patient with liver dysfunction due to vanishing bile duct syndrome resulting in a partial response without any severe adverse events
  Ishitsuka Kantaro; Yokoyama Yasuhisa; Baba Naoko; Matsuok...
  JOURNAL OF CLINICAL AND EXPERIMENTAL HEMATOPATHOLOGY/62(3)/pp.154-157, 2022-07-12
  
  PubMed
• Cardiac Tamponade as a Recurrence of Angioimmunoblastic T-Cell Lymphoma with the Detection of a p.Gly17Val RHOA Mutation in the Pericardial Effusion
  Tsuboi Yuri; Iimura Yumoe; Matsumura Fumiaki; Nanmoku ...
  INTERNAL MEDICINE/62(4)/pp.595-600, 2022-06-21
  
  PubMed
• [Acquired platelet dysfunction with severe bleeding tendency in triple-negative myelofibrosis]
  Momose Haruka; Nishikii Hidekazu; Kozuma Yukinori; Ota...
  [Rinsho ketsueki] The Japanese journal of clinical hematology/62(9)/pp.1406-1411, 2021-09
  
  PubMed
• Salvage Cord Blood Transplantation Using a Short-term Reduced-intensity Conditioning Regimen for Graft Failure.
  Suma S; Yokoyama Y; Momose H; Makishima K; Kiyoki Y; ...
  INTERNAL MEDICINE/61(11)/pp.1673-1679, 2021-11
• more...

Books

• 制御性T細胞による骨髄環境制御
  錦井 秀和
  医学のあゆみ/医歯薬出版/pp.1177-1182, 2019-03
• Chapter 14 Hematopoietic differentiation from Embryonic Stem Cells
  Yokoyama Y; Nishikii H; Chiba S
  Embryonic Stem Cells - Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine/InTech/pp.251-272, 2011-03

Conference, etc.

• Treatment outcomes of Tisagenlecleucel in Ibaraki prefecture
  樽井 裕太朗; 錦井 秀和; 栗田 尚樹; 丸山 ゆみ子; 小川 晋一; 清水 誠一; 渡邉 真威; 長谷川 雄...
  第46回日本造血･免疫細胞療法学会　総会/2024-03-21--2024-03-23
• Cases with myelofibrosis undergoing haploidentical hematopoietic stem-cell transplantation
  宮越敏宏; 栗田 尚樹; 丸山 ゆみ子; 小田 卓也; 海江田 拓実; 樽井 裕太朗; 松村 文明; 清木 祐介; ...
  第46回日本造血･免疫細胞療法学会　総会/2024-03-21--2024-03-23
• カルフィルゾミブ長期投与後に血栓性微小血管障害をきたした 1 例
  小田 卓弥; 横山 泰久; 海江田 拓実; 宮越 俊宏; 樽井 裕太朗; 松村 文明; 清木 祐介; 末原 泰人...
  第20回 日本血液学会関東甲信越地方会/2024-03-09--2024-03-09
• Purging myeloma cell contaminants simultaneously expanding peripheral blood mobilized stem cells
  Kantaro Ishitsuka; 錦井 秀和; Takaharu Kimura; Satoshi Ya...
  第85回 日本血液学会学術集会/2023-10-13--2023-10-15
• Distinct effects of TPO-RAs in polymer-based hematopoietic stem cells expansion system
  Riko Kikuchi; Kantaro Ishitsuka; Takaharu Kimura; 錦井 ...
  第85回 日本血液学会学術集会/2023-10-13--2023-10-15
• Surgery and rehabilitation in patients with acquired hemophilia A on emicizumab prophylaxis
  Yoshiyuki Ogawa; Kagehiro Amano; Keiji Nogami; Nobuaki...
  第85回 日本血液学会学術集会/2023-10-13--2023-10-15
• Surgery and rehabilitation in patients with acquired hemophilia A on emicizumab prophylaxis
  錦井 秀和
  第85回 日本血液学会学術集会/2023-10-13--2023-10-15
• Outcome of TP53-mutated myelodysplastic syndrome: a single center experience
  Yutaro Tarui; Tatsuhiro Sakamoto; Naoki Kurita; Yumiko...
  第85回 日本血液学会学術集会/2023-10-13--2023-10-15
• 造血幹細胞移植患者におけるタクロリムスとレテルモビルの薬物相互作用： タクロリムスの投与経路が薬物相互作用に及ぼす影響（第2報）
  森山 侑太; 末原 泰人; 坂本 竜弘; 加藤 貴康; 横山 泰久; 錦井 秀和; 千葉　滋; 鈴木 ...
  第49回日本臓器保存生物医学会学術集会/2023-10-20--2023-10-21
• Safety of romiplostim administered immediately after CBT: A phase 1 trial (PROMPT-1)
  Naoki Kurita; Hidekazu Nishikii; Yumiko Maruyama; Yasu...
  第85回 日本血液学会学術集会/2023-10-13--2023-10-15
• Survival of CB and haploidentical transplantation were comparable to HLA-matched transplantation
  Yoshizawa Yuki; Kurita Naoki; Maruyama Yumiko; Nishiki...
  The 13th JSH International Symposium 2023 in Tsukuba/2023-07-21--2023-07-22
• The genetic subtypes and the tumor microenvironment signatures in peripheral T-cell lymphoma
  Suehara Yasuhito; Sakamoto Kana; Fujisawa Manabu; Abe ...
  The 13th JSH International Symposium 2023 in Tsukuba/2023-07-21--2023-07-22
• エトポシド投与を回避し，正常分娩に至った妊娠 9 週発症血球貪食性リンパ組織球症の 1 例
  樽井 祐太朗; 末原 泰人; 服部 圭一朗; 佐々木 裕哉; 丸山 ゆみ子; 坂本 竜弘; 加藤 貴...
  第19回 日本血液学会関東甲信越地方会/2023-07-15--2023-07-15
• ELOVL6 regulates engraftment of hematopoietic cells through the PI3K pathway
  Kiyoki Yusuke; Kato Takayasu; Kito Sakura; Matsuzaka ...
  2nd JCA-AACR Precision Cancer Medicine International Conference/2023-06-28--2023-06-30
• 脊柱管内に腫瘤を形成したリンパ形質細胞性リンパ腫に対するチラブルチニブと放射線照射の併用療法
  普天間 幸愛; 栗田 尚樹; 坂本 竜弘; 加藤 貴康; 服部 圭一朗; 末原 泰人; 横山泰久; 錦...
  第63回 日本リンパ網内系学会学術集会・総会/2023-06-22--2023-06-24
• 後天性血友病A患者を対象としたエミシズマブの第III相臨床試験(AGEHA)：最終解析結果
  鈴木 伸明; 錦井 秀和; 天野 景裕; 小川 孔幸; 野上 恵嗣; 小林 亮太; 尾崎 凌斗; 米...
  第45回 日本血栓止血学会学術集会/2023-06-15--2023-06-17
• エミシズマブ開始後に免疫抑制療法が実施可能となった後天性血友病Aの一例：AGEHA試験コホート2
  錦井 秀和; 小林 亮太; 水野 成美; 尾崎 凌斗; 嶋 緑倫
  第45回 日本血栓止血学会学術集会/2023-06-15--2023-06-17
• The fatty acid elongase elovl6 is crucial for hematopoietic stem cell engraftment and leukemia propagation
  Kiyoki Yusuke; Kato Takayasu; Kito Sakura; Matsuzaka ...
  The EHA 2023 Hybrid Congress/2023-06-08--2023-06-11
• Screening of TPO receptor agonists for efficient ex-vivo expansion of human hematopoietic stem cells in polymer based culture system
  Riko Kikuchi; Kantaro Ishitsuka; Takaharu Kimura; 錦井 ...
  The 20th Stem Cell Research Symposium/2023-05-19--2023-05-20
• Elongation of long-chain fatty acids is crucial for hematopoietic stem cell engraftment and leukemia propagation
  Kato Takayasu; Kiyoki Yusuke; Kito Sakura; Matsuzaka ...
  The 20th Stem Cell Research Symposium/2023-05-19--2023-05-20
• 同種造血幹細胞移植後に発症した肝類洞閉塞症候群26例の後方視的検討
  宝田 亜矢子; 栗田 尚樹; 服部 圭一朗; 坂本 竜弘; 加藤 貴康; 横山 泰久; 錦井 秀和; ...
  第120回 日本内科学会総会/2023-04-14--2023-04-16
• 成人 T 細胞性白血病を発症した HTLV1 キャリア 間生体腎移植の 1 例
  高橋　一広; 末原　泰人; 古屋　欽司; 高橋　真由美; 錦井　秀和; 小田 竜也
  第57回 日本臨床腎移植学会/2024-2-14--2024-2-16
• Safety proof of romiplostim immediately after cord-blood transplantation: Results of a phase 1 trial
  Kurita N.; Maruyama Y.; Suehara Y.; Hattori K.; Sakam...
  48th Annual Meeting of the European-Society-for-Blood-and-Marrow-Transplantation (EBMT)/2022-03-19--2022-03-23
• 造血幹細胞移植患者におけるタクロリムスとレテルモビルの薬物相互作用：タクロリムスの投与経路が薬物相互作用に及ぼす影響
  森山侑太; 末原泰人; 坂本竜弘; 加藤貴康; 横山泰久; 錦井秀和; 千葉　滋; 鈴木嘉治; 本間 真人
  第48回日本臓器保存生物医学会学術集会/2022-11-04--2022-11-05
• Efficacy and Safety of Emicizumab Prophylaxis in Patients with Acquired Hemophilia a Who Were Deemed Ineligible for Immunosuppressive Therapy: Additional Data from the Ageha Study
  Nishikii Hidekazu; Suzuki Nobuaki; Kobayashi Ryota; Mi...
  64th Annual Meeting and Exposition of the American-Society-of-Hematology (ASH)/2022-12-10--2022-12-13
• more...

Teaching

2023-10 -- 2024-02	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2023-04 -- 2023-08	Clinical Oncology: Hematogenous Cancer	University of Tsukuba.
2023-04 -- 2023-08	Advanced Seminar in Medical Sciences	University of Tsukuba.
2023-10 -- 2024-02	Advanced Seminar in Medical Sciences	University of Tsukuba.
2023-10 -- 2023-12	Outline of Internal Medicine	University of Tsukuba.
2024-01 -- 2024-02	Hematology for Beginners	University of Tsukuba.
2022-04 -- 2022-08	Advanced Seminar in Medical Sciences	University of Tsukuba.
2022-10 -- 2023-02	Advanced Seminar in Medical Sciences	University of Tsukuba.
2023-01 -- 2023-02	Hematology for Beginners	University of Tsukuba.
2022-10 -- 2022-12	Outline of Internal Medicine	University of Tsukuba.
more...

Talks

• 造血幹細胞増幅技術の臨床応用への展望と課題
  錦井 秀和
  第30回日本輸血・細胞治療学会秋季シンポジウム/2023-10-26--2023-10-27

(Last updated: 2024-04-17)